Organ and Tumor Dosimetry with UniSyn MI™
When it comes to dosimetry in radiopharmaceutical therapy (RPT), you no longer need to guess. Leveraging UniSyn MI™’s powerful display and measurement functions is Joule – our organ and tumor dosimetry tool. Joule provides fast and precise dose calculations for indications like metastatic prostate or neuroendocrine cancer being treated with RPT or primary or metastatic liver cancer treated with selective internal radiation therapy (SIRT).
UniSyn MI™ and Joule were designed with flexibility and customization in mind so that you can perform dosimetry your way.
Efficiency and Reproducibility
It’s very clear that segmentation is the most time-consuming and variable step in the dosimetry workflow. To enhance efficiency and improve reproducibility, we’ve equipped UniSyn MI™ with an AI organ segmentation tool to automatically contour organs-at-risk (OAR) on CT images.
For tumor segmentation, threshold-based segmentation tools are available within UniSyn MI™.
This collection of tools makes Joule a nearly automatic dosimetry solution.
Essential Features
Here is a summary of the main features included with Joule.
- Multi- and single-time point time-activity integration.
- Support for quantitative SPECT/PET or planar data.
- Fast dose calculations following the MIRD Schema.
- Nuclear data for over 1200 radioisotopes (ICRP Publication 107).
- S-Values based on modern voxelized phantoms (ICRP Publication 133).
- Spherical tumor models with variable densities.
- No manual entry of time-activity data required.
- Dosimetry report exported to PACS.
Extended Features
In addition to the essential features described above, UniSyn MI™ and Joule have a few unique components to support greater flexibility and control.
Single-time point methods include the Hänscheid method as well as patient-specific approach. Patient-specific time-activity models can be created using multi-time point measurements to reduce imaging requirements between therapy cycles.
Separate regions-of-interest can be used to measure an organ volume and activity. This is helpful to compensate for the partial volume effects observed between SPECT/PET images compared with CT or simply when the activity distribution does not align with the organ boundaries.
Joule allows you to supplement the time-activity measurements derived from images with manually entered data measured elsewhere, like blood activity measurements acquired on a gamma counter.
